CD8A and neoplasm: Clinical studies have also demonstrated that radiotherapy not only leads to the expansion of CD8+T cells in vivo, but also induces the expression of new tumor-associated antigens, which are recognized by CD8+T cells5.Priming and activation of CD8+T cells causes a systemic immune response against tumor tissue, both irradiated or unirradiated 6,7, this phenomenon of radiotherapy leading to tumor response and control in non-irradiated areas has been described as a abscopal effect.