Notably, brain region-specific changes of G9a, a key histone methyltransferase (HMT) responsible for dimethylation of Lysine 9 on histone H3 (H3K9me2), a molecular marker associated with transcriptional silencing, has recently emerged as important contributor to different alcohol-related behaviors, including withdrawal-related anxiety, alcohol tolerance and dependence and in alcohol-related neurodevelopmental disorders (Benevento et al., 2015). The gene discussed is EHMT2; the disease is Anxiety.