CHRNA4 and respiratory failure: Allosteric ion channel modulation has greattherapeutic potential.18 In the case ofthe OPP, it has been hypothesizedthat resensitization of desensitized muscle-type nAChRs can counteractOPC-induced respiratory failure and other nAChR-induced symptoms.This principal concept is supported by the resensitization of a completelydesensitized α7 nAChR by PAMs like PNU120596.20 However, no PAM acting at the muscle-type nAChR, a majortarget in the OPP, has been described so far, and therefore, thisconcept could not be validated in vivo.