Organophosphate poisoning (OPP)by pesticide exposure or by nerve agents represents a serious conditionwith insufficient treatment options and possible long-term impairment.1−3 The primary effect of organophosphate compounds (OPCs) is an irreversibleblock of the pivotal enzyme acetylcholine esterase (AChE), resultingin the accumulation of acetylcholine and overstimulation of both nicotinic(nAChR) and muscarinic (mAChR) acetylcholine receptors in the CNSand PNS (cholinergic syndrome). The gene discussed is CHRNA4; the disease is organophosphate poisoning.