NLRP3 and Alzheimer disease: During AD development, electroacupuncture inhibits glial cell activation while modulating microglia polarization toward the M2 phenotype and increasing the anti-inflammatory factors IL-4 and IL-10 (Xie et al., 2021), Reducing the expression of NLRP3, cysteine-1, and IL-1β in the hippocampus (He et al., 2021).