On the other hand, promisingly, a recent study overexpressing a potassium channel transgene packaged into an AAV9 viral vector under control of the same CKIIa promoter found a robust reduction in seizure frequency in a mouse model of frontal lobe focal cortical dysplasia without any major behavioral effects (Almacellas Barbanoj et al., 2024). Here, KCNA3 is linked to Focal cortical dysplasia.