Taken together, our data imply that PHLDA1 silencing enhances the EGF receptor signaling pathway, but the influence is unidirectional since neither EGFR activation, nor inhibition does not generate changes in the PHLDA1 level in shCtrl cells (Figures 5A,B) and IMR-32 neuroblastoma cells (Supplementary Figures S11, S12). Here, PHLDA1 is linked to neuroblastoma.