TID1S448-453 may be beneficial for a number of neurodegenerative diseases, including FRDA, which have a mitochondrial biogenesis deficit (Calkins et al., 2011; Uittenbogaard and Chiaramello, 2014; Golpich et al., 2017) and aconitase 2 deficient disorders (Spiegel et al., 2012; Bouwkamp et al., 2018; Neumann et al., 2020; Park et al., 2020). This evidence concerns the gene ACO2 and neurodegenerative disease.