Differently, aspirin 100 mg/BID or 300 mg/d significantly reduced TXB2 levels in the colorectal tumor tissues associated with acetylation of COX-1 comparable to that found in normal tissue; these effects were associated with a restraining impact on the expression of protumorigenic genes (Figures 8B, C, 9B, C; Supplementary Figures S4B, C). Here, PTGS1 is linked to colorectal neoplasm.