The simple linear regression analysis of the % reduction of TXB2 levels and log2(fold change) of the expression of the 15 genes in colorectal tumor tissues by aspirin (all doses’ data were examined together) vs. the values assessed at predrug (baseline) showed that the % reduction of tumor TXB2 by aspirin inversely correlated with log2(fold change) of PTGS2 (COX-2), TWIST1 (twist-related protein 1) and VIM (vimentin) expression (Supplementary Figures S3A, B). Here, PTGS2 is linked to neoplasm.