In addition to the above mediators that can affect cardiac fibrosis through the STAT3 signaling pathway, there are other mediators that can affect myocardial fibrosis caused by ischemia/reperfusion, atrial fibrillation, diabetic heart disease, DCM, and hypertensive heart damage through the STAT3 signaling pathway (Table 2). The gene discussed is STAT3; the disease is familial dilated cardiomyopathy.