The analysis suggests that FANCD2, KITLG and TRIM65 are low‐risk genes in HCC, while CHGA, DDIAS, FOXK1, MAGEA3, MMP1, MSH2, MT3, RET, SLC1A5 and SLC7A11 are high‐risk genes for HCC. The gene discussed is MSH2; the disease is hepatocellular carcinoma.