CPT1A and nasopharyngeal carcinoma: For instance, CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma.28 Disruption of CPT1A through genetic or pharmacologic ways can cut off the supply of NADPH, thus preventing anchor-independent growth of ESCC cells and lung metastasis.29 Recently, CPT1A was identified as a succinyltransferase.