PDPK1 was identified as an early marker for aggressive PCa which participates in the regulation of PCa progression.32 PDPK1 promotes the proliferation of the AR‐negative PCa cells such as DU145 and PC3 via SGK3 activation, independent of the AKT pathway.33 Here, we demonstrated that SP5 and HOXA3 both can modulate the transcription of PDPK1 by binding to the promoter region. This evidence concerns the gene SP5 and posterior cortical atrophy.