IL17A and ischemia: Since inflammatory immune activation due to acute tissue hypoxia can occur in the ischemic phase, during which a series of signaling cascades mediated by expressed IL-17A through the corresponding receptors induces amplification of the inflammatory response, we hypothesized that inhibition of the inflammatory response before the onset of reperfusion injury (e.g. prior to the onset of ischemia and in the phase of ongoing ischemia) may be effective in attenuating the inflammatory storms that occur as a result of subsequent reperfusion.