Interestingly, BTG2 expression was recently found to be significantly elevated in liver tissues of mice or humans with alcoholic liver disease, while elevated expression of this gene was also seen in liver tissues of fasted and diabetic mice and diabetic patients, where overexpression of BTG2 enhances cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H to promote hepatic gluconeogenesis49,50. This evidence concerns the gene BTG2 and alcoholic liver diseases.