As a classical ligand for TNFRSF12A, tumor necrosis factor-related weak inducer of apoptosis (TWEAK) can be secreted by infiltrating macrophages in the liver, and the expression of TWEAK and TNFRSF12A was significantly increased during paracetamol-induced acute liver failure, and TNFRSF12A-induced apoptosis of hepatocytes could be significantly attenuated by the inhibition of the TWEAK/TNFRSF12A axis43. The gene discussed is TNFSF12; the disease is acute liver failure.