Inflammation-related pathways or biological processes were selected for presentation in Fig. 1E. IL-17 signaling pathway, oxidative phosphorylation, TNF signaling pathway, fluid shear stress and atherosclerosis, viral protein interaction with cytokine and cytokine receptor, and apoptosis were activated, and significantly enriched in HIRI samples (Fig. 1C,E). The gene discussed is IL17A; the disease is atherosclerosis.