Immunohistochemical staining revealed that YME1L levels were lower in the renal tubules of DKD patients compared to those of normal subjects, additionally, there was a slight decrease in the early stages, and a significant decrease in the later stages, while YME1L expression in the glomerular area was less affected in the diabetic state(Fig. 1B, C). The gene discussed is YME1L1; the disease is diabetic kidney disease.