APOB and Hypertension: Table 1 also shows that brain frailty is associated with the most factors, including age, duration of hypertension, smoking, history of previous stroke, multiple vessel occlusion, coronary heart disease, atrial fibrillation, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), location of occluded vessels, and PC occlusion.