In addition, CLL cells show elevated levels of the transcription factor NF-E2-related factor 2 (NRF2), also known as nuclear factor (erythroid-derived 2)-like 2, compared to mononuclear cells isolated from the PB of healthy donors, and several electrophilic compounds exert diverse levels of toxicity against leukemic cells; among them, it was suggested that dimethyl fumarate (DMF) may reduce the viability of CLL cells by electrophilic stress [28]. The gene discussed is NFE2L2; the disease is B-cell chronic lymphocytic leukemia.