PSMD7 and pachyonychia congenita: To understand the impact of increased PSMD7 expression on PC carcinogenesis, we transfected shPSMD7#1, shPSMD7#2,shPSMD7#3 and shNC interference plasmids into PANC-1 cells, and the qRT-PCR and Western blotting results showed that shPSMD7#2 and shPSMD7#3 interference plasmids had obvious effect on knockout (Supplymentment Fig. 1C, D).