Previous studies have found that PSMD7 is highly expressed in esophageal squamous cell carcinoma cells, and knockdown of PSMD7 leads to a decrease in proteasom activity and the ability of recognition to poly-ubiquitinated chain and cleavage of the protein from ubiquitinated chain, which inhibits the mTOR/p70S6K pathway and the proliferation of esophageal squamous cell carcinoma cells [13]. The gene discussed is RPS6KB1; the disease is esophageal squamous cell carcinoma.