We first evaluated the relationship between the expression of COX7A1 and our model, and found that the lower the expression of COX7A1 in GC patients with higher immune response ssGSEA score, indicating that COX7A1 may be a poor prognostic factor; then we analyzed the prognosis of COX7A1, and proved that COX7A1 was a poor prognostic factor in multiple data sets, while patients with high expression of COX7A1 were resistant to 5-Fu and oxaliplatin. The gene discussed is COX7A1; the disease is gastric cancer.