These data were further supported by increased staining of GLUT-1 (P < 0.0001) and Lat-1/Slc7a5 expression (P = 0.037) in the metastatic model compared with the primary tumor model (Fig. 5D; Supplementary Fig. S8), indicating higher glucose and amino acid uptake detectable by PET imaging during cancer progression in this primary and metastatic pair. Here, SLC2A1 is linked to neoplasm.