YY1, a transcription factor that regulates gene expression,[25] undergoes epigenetic modifications implicated in gene mediating.[30, 35, 36] In a study on chronic hepatitis, YY1 degradation via ubiquitination activated the HNF4 α/MiR‐122/CCL2 pathway,[35] while YY1 phosphorylation at S118 induced atherosclerosis.[36] Our previous study showed that YY1 lactylation contributed to elevated FGF2 expression.[30] Building on these findings, CUT&Tag analysis was performed to identify the downstream target genes of YY1 lactylation. Here, CCL2 is linked to atherosclerosis.