As shown in Fig. 7c, CPNE3 knockdown dramatically slowed tumor development in vivo (Fig. 7d, e), and the tumor weight of CDX (n = 10/group) models was significantly suppressed (mean ± standard error of the mean: sgRNA-CPNE3 vs. sgRNA-NC: 0.257 ± 0.028 vs. 0.716 ± 0.063; p < 0.01). Here, CPNE3 is linked to neoplasm.