The tumor growth rate of the PDX (n = 6/group) models significantly decreased after the intratumoral injection of the lentivirus encoding sgRNA-CPNE3, with the relative tumor proliferation rates value of 0.480 (mean relative tumor volume: sgRNA-CPNE3 vs. sgRNA-NC: 4.221 vs. 8.777; p < 0.01). Here, CPNE3 is linked to neoplasm.