The results of these analyses revealed that the expression of CPNE3, YAP1, RAD51, PIGK, MYC, NCOA6, and EP300 was higher in tumor tissues than in normal tissues, and CPNE3 expression was positively correlated with YAP1, RAD51, PIGK, MYC, NCOA6, and EP300 expression in patients with GC (Fig. 4a, b), suggesting that CPNE3 may positively regulate the Hippo-YAP1 signaling pathway. This evidence concerns the gene PIGK and gastric cancer.