Similar to IAPinh alone, exposure to S2/IAPinh correlated with a significant decrease in cIAP-1 protein levels, while cIAP-2 appeared to be unaffected in both pancreatic (HPAC, Fig. 4B and C) and ovarian cancer cells (OVCAR8, suppl. The gene discussed is BIRC2; the disease is ovarian carcinoma.