Inhibition of CD38 suppressed several other inflammatory signalling pathways activated by MSU crystals, especially pathways for IL-17 signalling and Th17 cell differentiation, which were also enriched in our previous genome-wide DNA methylation analyses of PBMCs of gout patients [40], chemokine and cytokine receptor binding and activity, and nuclear receptor activity. The gene discussed is CD38; the disease is gout.