The most downregulated genes were FCGR2B, which was previously connected to PC persistence in BM and higher susceptibility to apoptosis [24], LYZ, and ITPRIP. In addition, we observed decreased expression of deubiquitinase gene OTUD1, which we recently found associated with worse prognosis in MM patients [25]. The gene discussed is OTUD1; the disease is Miyoshi myopathy.