In detail, pancEts-1 directly interacts with NONO to increase its interaction with the Ets-related gene (ERG), resulting in increased transactivation of ERG, transcription of Ets-1, and promotion of growth and aggressiveness of GC cells, overall suggesting a crucial role of the pancEts-1/NONO/ERG/Ets-1 axis in GC progression (Fig. 4A) [45]. This evidence concerns the gene ERG and gastric cancer.