PIN1 and breast cancer: Furthermore, in BC, the interaction of the peptidyl–prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) with the C-terminal threonine–proline motifs of NONO increases the stability of NONO by inhibiting its proteasomal degradation, ultimately raising NONO expression levels and activating NONO-induced downstream signaling pathways involved in carcinogenesis [49].