In detail, NONO-mediated SETMAR-L expression increases histone methylation, ultimately leading to the transcriptional repression of multiple oncogenes, such as Peroxiredoxin 4 (PRDX4), Glucosidase alpha neutral AB (GANAB), and SET domain-containing protein 7 (SETD7), reported to be associated with cancer metastasis [58–60]. Here, PRDX4 is linked to cancer.