In HCC, NONO is highly expressed and modulates the splicing switch of BIN1-S to generate BIN1 long isoform (BIN1-L), which contains exon 12a and plays an oncogenic role through association with polo-like kinase 1 (PLK1) to enhance its protein stability [83], and finally promoting cell cycle progression (Fig. 6A). This evidence concerns the gene PLK1 and hepatocellular carcinoma.