Interestingly, recent studies from our group have revealed that chronic pharmacological stimulation of SERCA induces anxiety- and depressive-like behaviors, memory deficits, as well as sustained brain region-specific noradrenergic and serotonergic neurochemical alterations in mice, further highlighting the importance of dissecting the neurobiological implications of SERCA2-dependent Ca2+ regulatory mechanisms in the brain51,39. The gene discussed is ATP2A2; the disease is Anxiety.