PLN and Cognitive impairment: Interestingly, constitutive deletion of the Pln gene resulted in hyperactivity and cognitive deficits in Pln−/− mice as they traveled a greater distance in the OFT (Fig. 4a), and were outperformed by their Pln+/+ counterparts in the Y-maze and the NOR tests, with these behavioral deficits being indicative of impaired spatial working memory and long-term object recognition memory, respectively (Fig. 4c–e).