Indeed, compelling evidence suggests that SERCA plays a critical role in brain physiology and pathophysiology; SERCA2 dysregulation has been associated with several neuropsychiatric disorders, including schizophrenia, bipolar disorder, cerebral ischemia, alcoholism, as well as Alzheimer’s and Parkinson’s diseases (for review see17,62). The gene discussed is ATP2A2; the disease is brain ischemia.