CREBBP and neoplasm: Consistently, another study demonstrated that low expression of CREBBP or EP300 inhibits H3K27 acetylation via the FBXW7–NOTCH–CCL2/CSF1 axis to induce the polarisation of tumour-associated macrophages to the M2 phenotype and tumour cell progression in diffuse large B-cell lymphoma (DLBCL) [43].