CREBBP and cancer: Clinically, the expression of CREBBP was remarkably enhanced in various cancer tissues (Fig. S8), especially in HCC, compared with that in normal tissues (P < 0.001) (Fig. S9A) and resulted in lower OS (P = 0.009) (Fig. S9B), PFI (P = 0.00082) (Fig. S9C) and disease-free-interval (DFI; P = 0.0048) (Fig. S9D) in HCC.