Furthermore, a putative HOXD3-binding motif was predicted in the promoter region of CREBBP using the JASPAR database and UCSC Genome Browser, and the results of ChIP–PCR and dual-luciferase reporter assays verified the binding of endogenous HOXD3 to the abovementioned motif in HCC cells. Here, CREBBP is linked to hepatocellular carcinoma.