Histaminergic (Hdc) and arginine vasopressin/retinoic acid receptor-related orphan receptor β (Avp/Rorb) neuronal subpopulations and the well-known AgRP neurons were enriched in the male offspring specifically when their mothers were fed HFD, highlighting that maternal dietary exposure during lactation has significant effects on neurogenesis, particularly in male offspring, which may contribute to their later susceptibility to obesity when exposed to HFD themselves. This evidence concerns the gene AGRP and obesity due to melanocortin 4 receptor deficiency.