HDAC3 and obesity due to melanocortin 4 receptor deficiency: Previous studies suggested the roles of HDACs as key epigenetic players in obesity development and we observed a higher expression of Hdac3 per cell as well as a higher number of cells expressing Hdac3 in mLFD group (Padj < 0.001, mHFD vs mLFD) (Fig. 4d).