TLR4 and rheumatoid arthritis: We observed that macrophages did not influence sAxl, sMerTK, or Gas6 release by conditioned RA-FLS, independently of the macrophage polarisation status (Fig. 4E and Supplementary Fig. 4B); conversely, macrophages conditioned with TLR4-stimulated RA-FLS significantly decreased sMerTK release in the supernatants.