The most highly connected molecules including several related to cancer etiology (see Discussion) such as: TP53 (tumor protein p53)91; RB1 (RB transcriptional corepressor)93; CDKN2A (cyclin dependent kinase inhibitor 2A)94 and EGFR (epidermal growth factor receptor)95, plus RELA, a subunit of the heterodimeric transcription factor called NF-Kappa-B, related to substance abuse96. The gene discussed is RELA; the disease is cancer.