In a similar manner, none of the tumor vessel features of AT-3 tumors from mice with chronic severe thrombocytopenia were observed in mice with a genetic deficiency in platelet GPVI (Supplementary Fig. 13), a receptor which has been shown previously to intervene in the prevention of bleeding in inflamed organs and tumors [31, 36–39]. This evidence concerns the gene GP6 and Thrombocytopenia.