PF4 and Thrombocytopenia: In AT-3 tumors, thrombocytopenia caused a significant reduction in the levels of PF4 and CXCL-10, and an increase in those of several major mediators of immune cell recruitment and activation, including MCP-1, IFN-γ, RANTES, P-selectin, macrophage inflammatory protein-1 α and β (MIP-1α/β), MIP-3β, interleukin-1β (IL-1β) and CXC chemokine KC (CXCL1) (Fig. 9A).