In particular, as compared to B16F1 melanoma, AT-3 tumors were enriched in mediators of leukocyte infiltration, including chemokines like RANTES, MCP-1 and − 5, fractalkine, CXCL9, 10 and 16, as well as endothelial adhesion molecules like ICAM-1 and VCAM-1 (Figs. 1A and 2A). Here, CX3CL1 is linked to melanoma.