MALAT1 and osteoporosis: To study the role of Malat1 in osteoclastogenesis and osteoporosis in vivo, we used a Malat1-knockout mouse model (Malat1−/−) described in our previous study, in which a transcriptional terminator was inserted downstream of the transcriptional start site of Malat1, causing the loss of Malat1 RNA expression without altering expression levels of Malat1’s adjacent genes22.