We then analyzed the expression of MALAT1 in pre-osteoclasts (including monocytes and macrophages) and mature osteoclasts of the non-osteoporotic individual (Fig. 4a, b), osteoporosis patients (Fig. 4c, d), osteosarcoma patients (Fig. 4e, f), and patients with breast cancer bone metastases (Fig. 4g, h). This evidence concerns the gene MALAT1 and osteosarcoma.