Third, our previous study22 and the present study collectively demonstrate that Malat1 binds to Tead to inactivate Yap-Tead’s pro-metastatic function in cancer cells and to inhibit Nfatc1-Tead3’s pro-osteoclastogenic function in pre-osteoclasts, revealing both tumor-intrinsic and tumor-extrinsic mechanisms of Malat1 in metastasis suppression. The gene discussed is NFATC1; the disease is cancer.