To determine the correlation of the obtained 15 radioresistant genes with the prognosis of NSCLC patients, we performed univariate Cox regression analysis on the GSE37745 dataset, and found that SMAD3 had the most significant prognostic value in NSCLC, representing a high-risk gene (Fig. 2A). This evidence concerns the gene SMAD3 and non-small cell lung carcinoma.