IL31 and Alzheimer disease: The complex dermal milieu of immune cells/cytokines/receptor network including IL-31, OSM, IL-31RA, and OSMRβ may play an important role in the pathogenesis of pruritus in CPG.21, 22 However, in contrast to AD, M1/M2 macrophage activation, tumor necrosis factor production, dermal fibrosis, revascularization, and neural dysregulation are unique features of atopic CPG.23