Furthermore, the herein study revealed that the dietary prophylactic additives of UROEE, CsNPs and UROEE-CsNPs as well as the therapeutic treatment with CsNPs and UROEE-CsNPs but not UROEE could reduce the inflammatory response induced by E. tenella following primary and secondary infection through the reduction of the pro-inflammatory cytokine IL-6 mRNA expression, when compared to the positive control group. This evidence concerns the gene IL6 and infection.