IGHE and chronic rhinosinusitis with nasal polyps: Moreover, in CRSwNP patients, elevated levels of Th2-drive proinflammatory cytokines, such as IL-2, IL-5, IL-6, IL-10, IL-13, and IgE in the mucus collected from the olfactory cleft, have been associated with reduced scores for smell test identification [34, 35••, 38].