SMARCA1 and B-cell chronic lymphocytic leukemia: Chromatin remodelers consist of four families: SWI/SNF (SWItch/Sucrose Non-Fermentable), ISWI (Imitation of SWItch), CHD (Chromodomain Helicase DNA binding), and INO (INOsitol), which are subdivided by the core ATPase subunit and involved in many pathological processes in CLL.