Integrated analysis of DNA methylation identified that CLL stereotyped subset #8 (IGHV4-39/IGKV1(D)-39) demonstrated a unique DNA methylome compared with the other U-CLL cases, including subset #6 (IGHV1-69/IGKV3-20) and the hypomethylated and overexpressed TP63 gene becomes a pro-survival factor [37]. Here, TP63 is linked to B-cell chronic lymphocytic leukemia.