In HNSCC, recurrence and distant metastasis are facilitated by immune evasion,3 which is partially mediated by the expression of programed death receptor ligands 1 and 2 (PD‐L1 and PD‐L2, respectively), which bind programed death 1 (PD‐1), an immune‐checkpoint receptor that suppresses T cells.4, 5, 6, 7. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.