Hypoxanthine phosphoribosyl transferase 1 (HPRT1) plays a pivotal role in nucleotide recycling, critical for cell growth and biosynthesis, and its upregulation has been observed in various cancers, with implications for clinical outcomes,29 including breast cancer29 and head and neck squamous cell carcinoma.30 This evidence concerns the gene HPRT1 and head and neck squamous cell carcinoma.