Ipatasertib, an Akt inhibitor, has demonstrated good tolerability and safety when combined with chemotherapy or hormonal treatments for prostate cancer, though its effect on renal cell carcinoma remains unexplored [90, 91] Lapatinib, an EGFR/HER-2 tyrosine kinase inhibitor, exhibits better overall tolerance compared to hormonal therapy among advanced RCC patients who have progressed following initial cytokine treatment. Here, EGFR is linked to hereditary clear cell renal cell carcinoma.