NOTCH1 and cancer: After careful evaluation, 6 features including 1 gene mutation (FBWX7) and 5 reactome pathways (signaling by NTRKs, regulation of RAS by GAPs, TP53 regulates transcription of DNA repair genes, DNA double-strand break repair, and FBXW7 mutants and NOTCH1 in cancer) were selected to construct as a risk model defined as SRS.