Following adjustments for various covariates, including age, gender, educational attainment, annual income, smoking status, drinking status, physical activity, BMI, CHD, CLD, liver disease, CRP, WBC, Scr, Cystatin C, hemoglobin, FPG, HbA1c, lipid-lowering medication, antihypertensive medication, and glucose-lowering medication, a non-linear correlation between the TC/HDL-C ratio and the risk of stroke was identified (Table 5). The gene discussed is CST3; the disease is congenital secretory chloride diarrhea 1.