CKD-induced anxiety, cognitive impairment, astrocyte reactivation in the anterior cingulate cortex, and neuronal activity enhancement in the anterior cingulate cortex and hippocampal CA1 neurons were ameliorated after knocking out neural lineage-specific and astrocyte-specific AhR or treating with AhR antagonist CH223191. The gene discussed is AHR; the disease is Cognitive impairment.