CACNA1A and migraine, familial hemiplegic, 1: After the parents told the story of their daughter and the long diagnostic odyssey, the clinicians reviewed the complex symptomatology that has been reported to accompany pathogenic variants in CACNA1A. Termed CACNA1A-related disorders, (CRD), these include three different autosomal dominantly inherited neurological conditions: Familial Hemiplegic Migraine, type 1 (FHM1), Episodic Ataxia, type 2 (EA-2), and Spino-Cerebellar Ataxia, type 6 (SCA6)[5, 6].