Compared to the controls, the frequency of the APOE ɛ3/ɛ4 genotype was higher in the T2DM + CAD patients (22.0% vs. 10.4%, p < 0.001), and the frequency of the APOE ɛ3/ɛ3 genotype was lower (60.1% vs. 72.6%, p < 0.001). This evidence concerns the gene APOE and coronary artery disorder.