The logistic regression analysis showed that age ≥ 60 years old (adjusted OR = 5.12, 95% CI= 3.57–7.34, p < 0.001), BMI ≥ 24.0 kg/m2 (adjusted OR = 3.42, 95% CI = 2.28–5.12, p < 0.001), APOE ɛ3/ɛ4 genotype (adjusted OR = 1.93, 95% CI = 1.18–3.14, p = 0.008) and ɛ4 allele (adjusted OR = 1.97, 95% CI = 1.23–3.17, p = 0.005) were independent risk factors for T2DM + CAD. The gene discussed is APOE; the disease is coronary artery disorder.