Given that methyltransferase-like 3 (METTL3) and insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) are the key m6A methyltransferase “writer” and “reader”, respectively, in CRC cells, we evaluated METTL3 and IGF2BP2 expression and their correlation with POU6F2-AS1 in the TCGA database. The gene discussed is METTL3; the disease is colorectal carcinoma.