In detail, the mediated efficacy of CRP accounted for 15.9% in the associations between MAFLD and sarcopenia prevalence (IE = 0.039, 95%CI: 0.012–0.081; DE = 0.205, 95%CI: 0.134–0.272), while the mediated efficacy of HDL accounted for 18.9% (IE = 0.045, 95%CI: 0.026–0.065; DE = 0.195, 95%CI: 0.130–0.260). Here, CRP is linked to sarcopenia.