For the IgG autoantibodies, the severe COVID-19 group trended for higher levels in many of the analytes tested and had statistically significant higher levels of both IL-3 and IFNα2 cytokines (p ≤ 0.05; Wilcoxon–Mann–Whitney; Fig. 5a, Supplementary Fig. 3). The gene discussed is IFNA2; the disease is COVID-19.