In addition, fiber and collagen analysis by Masson trichrome staining indicated that collagen (blue) was decreased in the gefitinib-induced EGFRL858R*USP24C1695A drug resistant mice compared to gefitinib-induced EGFRL858R*USP24WT drug resistant mice, implying that USP24 might be involved in extracellular matrix (ECM) modelling during cancer therapy (Fig. 5C, lower panel). This evidence concerns the gene USP24 and cancer.