We found that the PD-L1 level was significantly decreased in the doxycycline-induced EGFRL858R*USP24C1695A drug-sensitive and drug-resistant mice compared to that in the doxycycline-induced EGFRL858R*USP24WT drug-sensitive and drug-resistant mice respectively, suggesting that USP24 can stabilize PD-L1 in lung cancer mice, which is involved in drug resistance during cancer therapy (Fig. 6F). This evidence concerns the gene CD274 and cancer.