After treatment for a long time (217th day), body weight of the mice treated with gefitinib only did not increase again (green arrow), and the tumor signal of lung micro-CT in the gefitinib-treated mice was slightly higher than that with the cocktail treatment of gefitinib and USP24-i-101 (Supplementary Fig. 6A, Supplementary Fig. 6B and Fig. 7D (b)). This evidence concerns the gene USP24 and neoplasm.