LC3-II was significantly increased in mitotic A549 cells but not in A549-T24 cells (Fig. 3E(a), Fig. 3E(b) and Fig. 3E(d)), implying that the downregulation of USP24 may induce autophagy to maintain genomic stability in drug-sensitive lung cancer cells but not in drug-resistant lung cancer cells (Fig. 3E). This evidence concerns the gene USP24 and lung cancer.