We also identified T cell clusters that were mostly enriched in different tissues, including Th17 cells (Meta_CD4_C5) in normal colon tissues, γδT cells (Meta_γδT) in colitis tissues, CXCR5+ Tfh cells (Meta_CD4_C7) in lung tumor tissues, and interferon-responsive T cells (Meta_CD8_C7) in arthritis synovial fluid (Supplementary information, Fig. S3f). This evidence concerns the gene CXCR5 and arthritic joint disease.