RTN4R and colitis: In addition to suppressing the inflammatory response and downregulating the expression of pro-inflammatory mediators in colitis mice, the Gene Ontology (GO) analysis also revealed an increase in the expression of genes associated with the meiotic cell cycle and DNA repair, as well as a reduction in the expression of genes associated with the response to wounding in the DSS + NGR1 group compared to the DSS group (Fig. 3c).